Satiety Signalling

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Figure 1. After ingestion of a meal, chemical and mechanical signals from the gut activate vagal afferents which project to the nucleus tractus
solitarius (NTS) in the medulla oblongata. From there, axons to the dorsal motor nucleus of the vagus (DMV) signal satiety by projecting back to
the gut. Fibres from the NTS also project to the medullary reticular formation and to the forebrain; these lead to motor control activity necessary to
terminate eating and to the feeling of lasting satiety, respectively.
Source: Berthoud, HR. (2008). The vagus nerve, food intake and obesity. Regulatory Peptides, 149, 15-25.
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